Traditional Uses: Traditionally used by Native American tribes as a bitter tonic for digestive complaints, loss of appetite, ulcers, and constipation, as well as for general sickness and skin conditions like eczema and psoriasis.
Potential Benefits: May help reduce mild-to-moderate plaque psoriasis symptoms when applied topically, exhibits antimicrobial (antibacterial and antifungal) and anti-inflammatory activity (primarily due to berberine), and may stimulate digestion as a bitter tonic, though human evidence of internal metabolic effects is limited.
Warnings: Generally considered safe for short-term use, but may cause gastrointestinal upset, itching, or rash; berberine can worsen jaundice in newborns, so avoid during pregnancy and breastfeeding; may interact with medications processed by the liver, cyclosporine, sedatives, and diabetes drugs.
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