Traditional Uses: Traditionally used by Native Americans and early colonial settlers as a tea or tonic for rheumatism, gout, fevers, diarrhea, skin diseases, and as a “blood purifier,” and was historically exported to Europe as a treatment for syphilis.
Potential Benefits: May possess antifungal, anti-inflammatory, and vasodilatory properties based on limited animal and laboratory studies, but there is no high-quality scientific evidence supporting its efficacy for any human health condition.
Warnings: Contains safrole, which is carcinogenic and hepatotoxic; internal use is unsafe and banned by the FDA, as even 5 mL of sassafras oil can be fatal; avoid entirely during pregnancy (may cause miscarriage), breastfeeding, and in children.




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